IMC Genomics
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Reproductive & Prenatal · IVF

Transfer the
euploid embryo

PGT-A screens IVF embryos across all 24 chromosomes before transfer. Knowing which embryos are chromosomally normal raises implantation rates, lowers miscarriage risk, and shortens time to a healthy pregnancy.

24
Chromosomes screened
Day 5/6
Trophectoderm biopsy
10–14d
Per cohort
Day 5/6 expanded blastocyst with trophectoderm biopsyCross-section of an expanded human blastocyst showing zona pellucida, blastocoel cavity, inner cell mass, and trophectoderm, with holding pipette and biopsy pipette aspirating 5–8 trophectoderm cells through a laser-assisted hatching site. Gardner grade 4AA, scale approximately 150 micrometers.Zona pellucidaglycoprotein shellInner cell mass→ fetusnot biopsiedBlastocoelfluid-filled cavityTrophectoderm→ placenta5–8 TE cells biopsiedflicked free · loaded intoPCR tube · whole-genome ampLaserhatching site≈ 150 µm4AA · Gardner
ISO 15189
Illumina NGS
Mosaicism reported
Why it matters

Implantation rate per transfer

Single-embryo transfers of PGT-A-screened euploid embryos consistently outperform unscreened transfers across published IVF registries. Numbers below reflect commonly cited ranges from peer-reviewed studies, not IMC internal claims.

Implantation rate per transfer by maternal age, with versus without PGT-APaired bar chart across five maternal age cohorts comparing implantation rate per single embryo transfer with PGT-A screened euploid embryos versus unscreened transfers. Error bars represent 95 percent confidence intervals; n per cohort is annotated under each bar pair.Implantation rate per transfer (%)By maternal age cohort · single embryo transfer0204060801007048< 35n = 412653835–37n = 358602638–40n = 294551441–42n = 186486> 42n = 92MATERNAL AGE AT RETRIEVAL (YEARS)With PGT-A · single euploid SETUnscreened SET95% CIAdapted from SART/CDC ART registry analyses and pooled euploid-SET cohort data; illustrative ranges, not IMC internal results.
Outcome data

Higher implantation. Fewer miscarriages.

Aneuploid embryos are the leading cause of IVF failure and early pregnancy loss. By transferring only chromosomally normal embryos, PGT-A increases the per-transfer success rate and reduces the emotional and clinical burden of failed cycles.

  • Single-embryo transfer becomes the norm — fewer twins.
  • Miscarriage rate drops with confirmed euploidy.
  • Time to live birth shortens, especially over age 35.
Embryo classification

Three result categories

Each biopsied embryo is classified by chromosomal copy-number profile.

EUPLOID

Normal copy number across all 24 chromosomes. Recommended for transfer.

MOSAIC

Mixed euploid and aneuploid cells. Reported with copy-number percentage; transfer decisions made with counseling.

ANEUPLOID

Whole-chromosome gain or loss. Not recommended for transfer.

How it works

From biopsy to result

1

Day 5/6 biopsy

Five to ten trophectoderm cells removed under embryologist control.

2

Tubing & freeze

Embryo vitrified; biopsy shipped frozen on dry ice.

3

WGA & sequencing

Whole-genome amplification followed by low-pass NGS on Illumina.

4

Copy-number call

Bioinformatics pipeline reports copy number for all 24 chromosomes.

5

Report

Embryo-by-embryo report delivered to your IVF clinic for transfer planning.

A note on mosaicism

Mosaic embryos, transparently reported

We report mosaic findings with the level of mosaicism — not as a single binary call. This gives your reproductive endocrinologist and genetic counselor the data they need to make individualized decisions.

LOW-LEVEL

20–40% aneuploid cells

Typically considered for transfer after counseling, often after euploid options are exhausted.

HIGH-LEVEL

40–80% aneuploid cells

Generally deprioritized; transfer decisions are case-by-case with detailed counseling.

SEGMENTAL

Partial chromosome change

Reported separately with size and location, since clinical implications differ by region.

Talk to our IVF team

If your clinic is considering PGT-A for a cycle, our embryology and bioinformatics teams can support biopsy logistics, shipping, and reporting end-to-end.